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Starting at the top left and then counter-clockwise: (1) creation of a tumor model in a small animal, (2) Experimental schedule with several arms, (3, 4) planning and execution of image-guided precision irradiation, (5) data collection and analysis, and (6) translation into the clinic. Figure 1.Įxample of a typical workflow in modern preclinical image-guided precision radiotherapy experiments. The latter is often far ahead of data handling methods currently employed in preclinical experiments. Other aspects such as defining research protocols, and efficient time-management of the workflow of experiments, could also be substantially improved by borrowing and adapting methods from clinical practice. in multimodality imaging longitudinal studies. orthotopic) and precision irradiation combined with imaging, 9,10 the current bottleneck is data storage, retrieval, communication and analysis for these experiments that may generate large amounts of data, e.g.

6–8 While there has been much recent progress in developing tumor models ( e.g. 5 Figure 1 shows a typical workflow of modern preclinical cancer research: starting from a biological model (cell culture, organoid, animal), response of normal or cancerous tissue to radiation combined with other agents is studied. Besides using radiation beams to destroy cancer cells, these platforms can be used to introduce selective damage in various organs. The novel radiation research platforms 3,4 that became available recently are heavily used for cancer research, but could also be used for other diseases in, e.g. In the upcoming field of image-guided precision radiation research, the aim is to empower preclinical animal trials of combinations of radiation with other agents such as drugs, chemotherapy, immunotherapy etc.

In particular, the DICOM standard is well supported by a wide range of imaging and treatment device manufacturers and healthcare IT support services. linear accelerators), DICOM (Digital Imaging and Communications in Medicine) 2 standards for images, treatment plans, dose distributions and structure delineations, which facilitate easy data processing and data transfer in the clinic and between different clinics. Examples hereof are PACS (Picture Archiving and Communication System) 1 treatment planning systems that include radiobiological modelling and can transfer treatment instructions to irradiation equipment ( e.g. In radiotherapy clinical practice it is common to handle large amounts of patient data with efficient data management systems.

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